On the Hardness of Bribery Variants in Voting with CP-Nets

We continue previous work by Mattei et al. (Mattei, N., Pini, M., Rossi, F., Venable, K.: Bribery in voting with CP-nets. Ann. of Math. and Artif. Intell. pp. 1--26 (2013)) in which they study the computational complexity of bribery schemes when voters have conditional preferences that are modeled by CP-nets. For most of the cases they considered, they could show that the bribery problem is solvable in polynomial time. Some cases remained open---we solve two of them and extend the previous results to the case that voters are weighted. Moreover, we consider negative (weighted) bribery in CP-nets, when the briber is not allowed to pay voters to vote for his preferred candidate.Comment: improved readability; identified Cheapest Subsets to be the enumeration variant of K.th Largest Subset, so we renamed it to K-Smallest Subsets and point to the literatur; some more typos fixe

Exploiting bounded signal flow for graph orientation based on cause-effect pairs

Background: We consider the following problem: Given an undirected network and a set of sender–receiver pairs, direct all edges such that the maximum number of “signal flows ” defined by the pairs can be routed respecting edge directions. This problem has applications in understanding protein interaction based cell regulation mechanisms. Since this problem is NP-hard, research so far concentrated on polynomial-time approximation algorithms and tractable special cases. Results: We take the viewpoint of parameterized algorithmics and examine several parameters related to the maximum signal flow over vertices or edges. We provide several fixed-parameter tractability results, and in one case a sharp complexity dichotomy between a linear-time solvable case and a slightly more general NP-hard case. We examine the value of these parameters for several real-world network instances. Conclusions: Several biologically relevant special cases of the NP-hard problem can be solved to optimality. In this way, parameterized analysis yields both deeper insight into the computational complexity and practical solving strategies. Background Current technologies [1] like two-hybrid screening ca

Towards a Dichotomy for the Possible Winner Problem in Elections Based on Scoring Rules

To make a joint decision, agents (or voters) are often required to provide their preferences as linear orders. To determine a winner, the given linear orders can be aggregated according to a voting protocol. However, in realistic settings, the voters may often only provide partial orders. This directly leads to the Possible Winner problem that asks, given a set of partial votes, whether a distinguished candidate can still become a winner. In this work, we consider the computational complexity of Possible Winner for the broad class of voting protocols defined by scoring rules. A scoring rule provides a score value for every position which a candidate can have in a linear order. Prominent examples include plurality, k-approval, and Borda. Generalizing previous NP-hardness results for some special cases, we settle the computational complexity for all but one scoring rule. More precisely, for an unbounded number of candidates and unweighted voters, we show that Possible Winner is NP-complete for all pure scoring rules except plurality, veto, and the scoring rule defined by the scoring vector (2,1,...,1,0), while it is solvable in polynomial time for plurality and veto.Comment: minor changes and updates; accepted for publication in JCSS, online version available

T cell derived IL-10 is dispensable for tolerance induction in a murine model of allergic airway inflammation

Regulatory mechanisms initiated by allergen specific immunotherapy are mainly attributed to T cell-derived IL-10. However, it has not been shown that T cell-derived IL-10 is required for successful tolerance induction. Here, we analyze cellular sources and the functional relevance of cell type specific IL-10 during tolerance induction in a murine model of allergic airway inflammation. While tolerance induction was effective in IL-10 competent mice, neutralizing IL-10 prior to tolerogenic treatment completely abrogated the beneficial effects. Cellular sources of IL-10 during tolerance induction were identified by using transcriptional reporter mice as T cells, B cells and to a lesser extent DCs. Interestingly, tolerance induction was still effective in mice with T cell-, B cell-, B and T cell- or DC-specific IL-10 deficiency. In contrast, tolerance induction was not possible in mice lacking IL-10 in all hematopoetic cells, while it was effective in bone marrow chimera that lacked IL-10 only in non-hematopoetic cells. Taken together, allergen specific tolerance depends on IL-10 from hematopoetic sources. The beneficial effects of allergen specific immunotherapy cannot solely be attributed to IL-10 from T cells, B cells or even DCs, suggesting a high degree of cellular redundancy in IL-10 mediated tolerance